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data-pid="lcnW-1KP" style="margin-bottom: 10px;">類器官（organoids）是利用干細胞或患者組織在3D培養條件下形成的多細胞立體結構，在結構以及功能上高度模擬人體器官和病變組織（如癌癥），能夠形成器官類似的空間結構并且分化出對應功能，具備增殖分化、自我組裝、長期培養、穩定遺傳等特點。</p><p data-pid="osI8b5_x" style="margin-bottom: 10px;">類器官可以作為多種疾病的體外模型，使深入探究人類疾病本質和制定有效干預措施成為可能，在藥敏檢測、新藥研發、疾病發生機理、新靶標發現、診療新策略探索、再生醫學等多個方面擁有廣泛的應用前景。</p><p style="margin-bottom: 10px;"><br/></p><p><br/></p><figure data-size="normal"><div style="margin-bottom: 10px;"><p style="text-align: center;"><img src="https://img67.chem17.com/9/20230719/638253535663432220875.webp" data-size="normal" data-rawwidth="1080" data-rawheight="673" width="1080" data-original="https://pic1.zhimg.com/v2-4b78e1d45ae2898fbb7582d1293e877c_r.jpg" data-actualsrc="https://pic1.zhimg.com/v2-4b78e1d45ae2898fbb7582d1293e877c_b.jpg" data-original-token="v2-4b78e1d45ae2898fbb7582d1293e877c" height="673" data-lazy-status="ok" style="display: block; margin: 0px auto; max-width: 100%; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044;"/></p></div><figcaption style="text-align: center;">?；锱囵B的部分類器官高清圖像</figcaption></figure><p><br/></p><p><br/></p><p><br style="margin-bottom: 10px;"/></p><h2 style="margin-bottom: 10px;">類器官培養示意圖</h2><p><br style="margin-bottom: 10px;"/></p><p style="margin-bottom: 10px;"><br/></p><p><br/></p><figure data-size="normal"><p id="_img_parent_tmp" style="text-align: center;"><img src="https://img67.chem17.com/9/20230719/638253535666400763569.webp" data-caption="" data-size="normal" data-rawwidth="694" data-rawheight="223" width="694" data-original="https://pic4.zhimg.com/v2-c8c98abc5b5630c6127447c531e7fb8b_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-c8c98abc5b5630c6127447c531e7fb8b_b.jpg" data-original-token="v2-c8c98abc5b5630c6127447c531e7fb8b" height="223" data-lazy-status="ok" style="display: block; margin: 0px auto; max-width: 100%; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044;"/></p></figure><p><br/></p><p><br/></p><p data-pid="LqDhV6-L">傳統培養時，二維細胞平鋪于培養皿底部，分泌因子直接進入培養基中，難以形成有效的細胞旁分泌。細胞間作用力微弱，而培養基中的營養物質或者藥物，無差別作用于每個細胞。在一些藥物測試時，藥物進入培養基后常常會對細胞進行無差別的殺死，難以模擬實際體內藥物作用過程。</p><p data-pid="ss-yvd8_">類器官在基質膠包裹下，基質膠支撐著細胞生長，形成立體結構，在特定培養基誘導下向不同方向分化生長。外部養分進入培養基后，基質膠與類器官外圍細胞會像體內情況一樣具有屏障作用。營養物質滲透形成濃度梯度、細胞代謝產物、分泌因子，形成局部微環境，更好的模擬體內環境。</p><p><br/></p><h2>類器官應用領域</h2><p><br/></p><p><br/></p><figure data-size="normal"><img src="https://img67.chem17.com/9/20230719/638253535670782314668.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="467" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic1.zhimg.com/v2-1754b6b65babdd51cebb1552d7936c0c_r.jpg" data-actualsrc="https://pic1.zhimg.com/v2-1754b6b65babdd51cebb1552d7936c0c_b.jpg" data-original-token="v2-1754b6b65babdd51cebb1552d7936c0c" height="467" data-lazy-status="ok" style="display: block; margin: 0px auto; max-width: 100%; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044;"/></figure><p><br/></p><p><br/></p><p><br/></p><p data-pid="Bibs0L_P"><br/></p><h2>類器官取樣流程</h2><p><br/></p><p><br/></p><figure data-size="normal"><img src="https://img67.chem17.com/9/20230719/638253535673282495743.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="331" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic3.zhimg.com/v2-6d32d13538106553124d4f30b816309a_r.jpg" data-actualsrc="https://pic3.zhimg.com/v2-6d32d13538106553124d4f30b816309a_b.jpg" data-original-token="v2-6d32d13538106553124d4f30b816309a" height="331" data-lazy-status="ok" style="display: block; margin: 0px auto; max-width: 100%; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044;"/></figure><p><br/></p><p><br/></p><p><br/></p><h2>我們的技術創新點和優勢</h2><p><br/></p><p>國產替代產品之一：基質膠</p><p data-pid="yORJtw3q">?；锘|膠，獨立自主研發，能更真實的再現體內的細胞和細胞，細胞和基質之間的關系；分離自具有自主知識產權的經基因編輯的小鼠腫瘤細胞株。</p><p><br/></p><p data-pid="G061a1bk">國產替代產品之二：類器官培養基</p><p data-pid="0EdR-CXn">培養基配方中，添加了高活力的Wnt3a蛋白等多種因子，且經過多次迭代升級，類器官生長顯著優于其它品牌。Wnt3a等細胞因子，擁有獨立自主知識產權，且能夠自產。</p><p><br/></p><p data-pid="uIUfaiNn">類器官培養檢測系統智能化升級：智能觀察與分析</p><p data-pid="nlcHQNoi">1.顯微鏡置于培養系統，對類器官進行原位實時觀測，并進行多焦深掃描；</p><p data-pid="PRG766yw">2.機器可以對實驗對象進行全天候全程跟蹤并拍攝，并對實驗結果進行分析，并能遠程分享數據，方便實驗進程的質量管理。</p><p><br/></p><p data-pid="D2C2Pesf">內流控式類器官培養芯片</p><p data-pid="d-QajKgP">通過音樂列表編程控制產生并控制培養皿中的微流；</p><p data-pid="oT5os4Lp">通過巧妙設置導流環及開口得到穩定的微流循環通路；</p><p data-pid="cq8HjNuU">通過微流控培養皿中間的人工細胞巢內部的超慢微環流精密控制內器官微環境。</p><p data-pid="CN3XGa7R">用這項技術自動化培養類器官，只需每2天添加5滴培養基即可。</p><p><br/></p><p data-pid="ccwp2qu0">類器官培養耗材高通量改造升級</p><p data-pid="GoVjEh3i">1.設計并開發吸頭引流支架能進行單次多道加樣，且位于中心點，方便自動化設備定位觀察；</p><p data-pid="5Q5qNLOt">2.設計并開發高通量類器官培養支架，能夠實現快速整版換液，有利于后期自動化方案整合。</p><p><br/></p><h2>我們的服務范圍</h2><p data-pid="iekyxO-U">類器官培養服務范圍包括多種組織，應用廣泛，涉及發育生物學、疾病病理學、細胞生物學、再生機制、精準醫療以及藥物毒性和藥效試驗等。</p><p><br/></p><p><br/></p><figure data-size="normal"><img src="https://img67.chem17.com/9/20230719/638253535675157673249.webp" data-caption="" data-size="normal" data-rawwidth="986" data-rawheight="864" class="origin_image zh-lightbox-thumb lazy" width="986" data-original="https://pic3.zhimg.com/v2-743b2c773196f6e69934188c50a59c86_r.jpg" data-actualsrc="https://pic3.zhimg.com/v2-743b2c773196f6e69934188c50a59c86_b.jpg" data-original-token="v2-743b2c773196f6e69934188c50a59c86" height="864" data-lazy-status="ok" style="display: block; margin: 0px auto; max-width: 100%; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044;"/></figure><p><br/></p><p><br/></p><p><br/></p><h2>我們的服務優勢</h2><p data-pid="fRm38kWW">四大技術研發中心：公司擁有蛋白表達純化中心、實驗動物中心、類器官研究中心和智能顯微觀察研究中心四大技術平臺。</p><p data-pid="w27gIRMR">多樣模型服務：提供多種模式的類器官培養以符合客戶的需求，模型構建效率高。</p><p data-pid="pMNeWsLh">強大技術實力：團隊力量雄厚，科研意志堅定，學術態度嚴謹，大膽嘗試，勇于創新。</p><p data-pid="zCN7D00R">嚴格質檢流程：模型質控體系嚴格，嚴格把控操作流程及質量指標，保證數據的穩定性、一致性與真實性。</p><p data-pid="V0i-eC1j">保證信息安全：按照保密安全和信息安全體系框架和管理要求，嚴格執行保密制度，確保信息安全。</p><p data-pid="X2v3_kLx">提供定制化服務：我們根據客戶實驗要求提供濃度值定制服務，提供技術支持與產品培訓。</p><p data-pid="KpIL4Ov1">完善的售后服務：我們提供一對一服務、代理商培訓、月度培訓、季度培訓、直播課程共享等。</p><p><br/></p><h2>我們的服務流程</h2><p data-pid="MaUM1sfW">1.需求分析</p><p data-pid="H_8yrRU1">2.評估報價</p><p data-pid="eu7mtLtp">3.意向確認</p><p data-pid="ZOWBCPv8">4.合同簽訂</p><p data-pid="_XAZQLzR">5.產品交付</p><p data-pid="XRqZrTK9">6.客戶驗收</p><p data-pid="laPfAfA7">7.售后服務</p><p><br/></p><h2>技術服務價格體系</h2><p><br/></p><p><br/></p><figure data-size="normal"><img src="https://img67.chem17.com/9/20230719/638253535676095105248.webp" data-caption="" data-size="normal" data-rawwidth="1080" data-rawheight="628" class="origin_image zh-lightbox-thumb lazy" width="1080" data-original="https://pic4.zhimg.com/v2-1626b66cb82aeb66d499fcc4661d5283_r.jpg" data-actualsrc="https://pic4.zhimg.com/v2-1626b66cb82aeb66d499fcc4661d5283_b.jpg" data-original-token="v2-1626b66cb82aeb66d499fcc4661d5283" height="628" data-lazy-status="ok" style="display: block; margin: 0px auto; max-width: 100%; height: auto; cursor: zoom-in; animation: 0.5s ease-in 0s 1 normal none running animation-1yvu044;"/></figure><p><br/></p><p><br/></p><p><br/></p><h2>關于?；?/h2><p data-pid="OQrEge2X">廈門?；锟萍加邢薰荆╔iamen Mogengel）位于中國·廈門國家高新技術創業中心。公司致力于3D細胞培養核心原材料的研發與產業化升級。目前公司的產品有基質膠、類器官培養基、細胞因子、3D細胞培養耗材、3D細胞培養智能顯微鏡等。公司擁有4大技術研發中心：分子克隆和細胞編輯中心、實驗動物中心、蛋白表達和純化平臺、類器官質檢系統和自動化。</p><p data-pid="UIGSVlGk">團隊擁有十余年類器官技術研究基礎，實力雄厚，科研意志堅定，學術態度嚴謹，大膽嘗試，勇于創新。公司推出的基質膠、類器官培養試劑盒等產品廣泛適用于類器官培養、血管生成實驗、細胞侵襲（transwell）實驗、PDX、CDX模型實驗、腫瘤球培養、腫瘤移植、皮下成瘤實驗、干細胞培養及細胞分化研究以及其他待開發實驗類型。</p><p><br/></p><p><br style="text-wrap: wrap;"/></p><p><br/></p> </div> <div class="art-next"> <dl class="shangxia"> <dd>上一篇：<a href="/Article-3422753.html">【干貨分享】小鼠膽管類器官原代建立Protocol</a></dd> <dd>下一篇：<a 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